Balanced salt solution

PHARMACOLOGIC CATEGORY
Irrigating Solution
Ophthalmic Agent, Miscellaneous

DOSING: ADULTS — Irrigation: Based on standard for each surgical procedure

DOSING: ELDERLY — Refer to adult dosing.

DOSAGE FORMS — Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, irrigation [preservative free]: Sodium chloride 0.64%, potassium chloride 0.075%, calcium chloride 0.048%, magnesium chloride 0.03%, sodium acetate 0.39%, sodium citrate 0.17% (500 mL)

Solution, ophthalmic [irrigation; preservative free]: Sodium chloride 0.64%, potassium chloride 0.075%, calcium chloride 0.048%, magnesium chloride 0.03%, sodium acetate 0.39%, sodium citrate 0.17% (18 mL, 500 mL)
AquaLase™ : Sodium chloride 0.64%, potassium chloride 0.075%, calcium chloride 0.048%, magnesium chloride 0.03%, sodium acetate 0.39%, sodium citrate 0.17% (90 mL)
BSS®: Sodium chloride 0.64%, potassium chloride 0.075%, calcium chloride 0.048%, magnesium chloride 0.03%, sodium acetate 0.39%, sodium citrate 0.17% (15 mL, 30 mL, 250 mL, 500 mL)
BSS Plus®: Sodium chloride 0.71%, potassium chloride 0.038%, calcium chloride 0.015%, magnesium chloride 0.02%, sodium phosphate 0.042%, sodium bicarbonate 0.21%, dextrose 0.092%, glutathione 0.018% (250 mL, 500 mL)
Navstel®: Sodium chloride 0.71%, potassium chloride 0.038%, calcium chloride 0.015%, magnesium chloride 0.02%, sodium phosphate 0.042%, sodium bicarbonate 0.21%, dextrose 0.092%, glutathione 0.018%, hypromellose 0.125% to 0.173% (250 mL, 500 mL)

DOSAGE FORMS: CONCISE
Solution, irrigation [preservative free]: Sodium chloride 0.64%, potassium chloride 0.075%, calcium chloride 0.048%, magnesium chloride 0.03%, sodium acetate 0.39%, sodium citrate 0.17% (500 mL)

Solution, ophthalmic [irrigation; preservative free]: Sodium chloride 0.64%, potassium chloride 0.075%, calcium chloride 0.048%, magnesium chloride 0.03%, sodium acetate 0.39%, sodium citrate 0.17% (18 mL, 500 mL)
AquaLase™ : Sodium chloride 0.64%, potassium chloride 0.075%, calcium chloride 0.048%, magnesium chloride 0.03%, sodium acetate 0.39%, sodium citrate 0.17% (90 mL)
BSS®: Sodium chloride 0.64%, potassium chloride 0.075%, calcium chloride 0.048%, magnesium chloride 0.03%, sodium acetate 0.39%, sodium citrate 0.17% (15 mL, 30 mL, 250 mL, 500 mL)
BSS Plus®: Sodium chloride 0.71%, potassium chloride 0.038%, calcium chloride 0.015%, magnesium chloride 0.02%, sodium phosphate 0.042%, sodium bicarbonate 0.21%, dextrose 0.092%, glutathione 0.018% (250 mL, 500 mL)
Navstel®: Sodium chloride 0.71%, potassium chloride 0.038%, calcium chloride 0.015%, magnesium chloride 0.02%, sodium phosphate 0.042%, sodium bicarbonate 0.21%, dextrose 0.092%, glutathione 0.018%, hypromellose 0.125% to 0.173% (250 mL, 500 mL)

GENERIC EQUIVALENT AVAILABLE — Yes

USE
Irrigation solution for ophthalmic surgery:
AquaLase™ , BSS®: Intraocular or extraocular irrigating solution
BSS Plus®, Navstel®: Intraocular irrigating solution

Irrigation solution for eyes, ears, nose, or throat

ADVERSE REACTIONS SIGNIFICANT
>10%: Ocular: Intraocular pressure increased (11% to 12%), cataract (7% to 11%)

1% to 10%:
Central nervous system: Headache (3%)
Ocular: Discomfort (3% to 5%), dry eyes (3% to 5%), macular edema (4%), conjunctival hyperemia (3% to 4%), posterior capsule opacification (2% to 3%), iritis (1% to 3%), retinal hemorrhage (1% to 3%), blurred vision (1% to 2%)

CONTRAINDICATIONS — Injection or I.V. infusion; use during electrosurgical procedures

WARNINGS / PRECAUTIONS
Disease-related concerns: Diabetes: Use with caution in patients with diabetes mellitus; intraoperative lens changes have been observed when undergoing vitrectomy procedure.

Other warnings/precautions: Appropriate use: For use during surgical procedures with an expected duration ≤ 60 minutes.

DRUG INTERACTIONS — There are no known significant interactions.

PREGNANCY RISK FACTOR — C (show table)

LACTATION — Excretion in breast milk unknown/use caution

CANADIAN BRAND NAMES — BSS Plus®; BSS®; Eye-Stream®

INTERNATIONAL BRAND NAMES — Balanced Salt Solution (DK, FI, GB, NZ)